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Thus, it is essential to consider that various factors, including patient characteristics, disease progression, and treatment duration, might influence the antioxidative effects of metformin ( The main ongoing clinical trials based on metformin intervention evaluating antioxidant properties were collected in Table 3 (Table 3)

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There is no clear evidence of harm from long-term glutathione supplementation at the doses used clinically, and many of our patients run maintenance protocols for years without issue

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[148] [157] It is for these reasons that clomipramine, in spite of potentially superior effectiveness to SSRIs, is now rarely used as a first-line agent in the treatment of OCD, with SSRIs being used as first-line therapies instead and clomipramine generally being reserved for more severe cases and as a second-line agent